All the bits of evolution: Computational biology and genomics

CoverThe April 13, 2012 issue of Science is devoted to Computational Biology and has an interesting and informative article on furthering our understanding of the course of evolution through the use of computational genomics. Below is a quote that sums up the role and potential of computational genomics, but I found the whole article (including the figure on pg 181) to be a helpful overview of the basics of building and evolving genomes, genomics and the potential application of the knowledge that can be gleaned by reducing genomes to bits.

From Integrating Genomes, Zerbino, et al. Science 13 April 2012,

Combining evolutionary, mechanistic, and functional models, computational genomics interprets genomic data along three dimensions. A gene is simultaneously a DNA sequence evolving in time (history), a piece of chromatin that interacts with other molecules (mechanism), and, as a gene product, an actor in pathways of activity within the cell that affect the organism (function).

Leave a Reply

Please log in using one of these methods to post your comment:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: