Viruses: An Antibiotic Alternative?

Evolution in a toxic world

[Image: Maryland Pharmaceutical Company’s REM – Virus! Virus! “I’ve got the Virus!” (1953)]

A toddler suddenly becomes deathly ill. In the ER she is diagnosed with dysentery, caused by a rare but particularly aggressive form of Salmonella. One antibiotic after another fails because the strain, picked up when her family was traveling across parts of Asia, resists multiple antibiotics; but there is an alternative new drug. Like a guided missile, the drug targets only the disease causing Salmonella. Not only that, but as long as Salmonella remains, the drug particles replicate, increasing in number until the infection subsides. Despite the carnage, the toddler’s gut microbiome remains unharmed – no need for probiotics or fear of complications like C. diff.  If Salmonella responds by evolving resistance, the drug may respond in turn engaging an ages old evolutionary dance. By the next morning the color returns to her cheeks. By evening…

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